How to Launch a Newsletter on Entrepreneurship on Substack in 2025
In 2025, entrepreneurship is more than just a buzzword—it’s a lifestyle, an economy, and a cultural shift. From solo founders to side hustlers, the appetite for actionable, trustworthy content about starting and scaling businesses has never been higher. The rise of indie creators and digital solopreneurs makes entrepreneurship one of the most fertile themes for building a high-impact newsletter on Substack.
In this article, you’ll get:
A strategic breakdown of why this niche still has massive potential
The psychographic profile of your ideal reader
A step-by-step structure for crafting irresistible content
Growth and monetization tactics tailored to this vertical
Proven examples of successful newsletters in the space
🎯 Ideal for: solo founders, business curators, indie consultants, side hustle enthusiasts, and all Substack creators exploring entrepreneurial themes.
Don’t forget: if you’re serious about building a high-performing newsletter in 2025, I’ve explored 55 strategic Substack niches in my book Newsletter Empire. It’s a compact, actionable playbook for creators who want clarity and momentum. Check the description on Amazon for a full overview of what’s inside.
1. Theme
Entrepreneurship
Entrepreneurship remains a top-tier topic on Substack and beyond, driven by a global shift toward independence, remote work, and digital-first income streams. According to Google Trends and Substack's own analytics, interest in content related to startups, solopreneurship, and bootstrapping has grown steadily post-2020, with spikes around economic downturns and tech layoffs—both seen as catalysts for going solo.
The opportunity? Most business content is generic or bloated. A focused, opinionated, well-structured newsletter on entrepreneurship can cut through the noise—especially if it blends real experience, curated resources, and community.
2. Target Audience
Who subscribes to entrepreneurship newsletters? Three main segments: